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Contraindications : Contraindicated in active liver disease, renal impairment, unexplained increase in transaminases and in hypersensitivity to simvastatin. Simvastatin oral tablet can interact with other medications, vitamins, or herbs you may be taking. It will take only 2 minutes to fill in. Drug interactions are reported among people who take Losartan and Simvastatin. Concomitant administration of gemfibrozil, cyclosporine, or danazol [see Warnings and Precautions (5.1)]. Also patients who have a liver disease should not take Simvastatin. You’ve accepted all cookies. Simvastatin also raises HDL-cholesterol (8 to16%) and therefore lowers the LDL-C/HDL-C and In patients taking simvastatin 80 mg for whom an interacting agent is needed, a lower dose of simvastatin or an alternative statin-based regimen with less potential for drug-drug interactions should be used (see below Measures to reduce the risk of myopathy caused by medicinal product interactions and sections 4.2, 4.3, and 4.5). myopathy. Simvastatin — manufacturer advises avoid. Reducing simvastatin dose to 20mg–most patients can be managed this way as the interaction with amlodipine leads to an increase in simvastatin exposure that is similar to taking simvastatin 40mg alone. Drug interactions are reported among people who take Melatonin and Simvastatin. Note that both itraconazole and statins can increase the risk of hepatotoxicity. Concomitant administration of strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat-containing products) [see Warnings and Precautions (5.1)]. Simvastatin tablets are contraindicated in the following conditions: • 1. Pregnancy and nursing period. • Pregnancy and breast-feeding (see also section 4.6). Coadministration of mifepristone and simvastatin increased simvastatin and simvastatin acid exposure by 10.4-fold and 15.7-fold, respectively, in drug interaction studies. The study is created by eHealthMe based on reports of 10,641 people who take Losartan and Simvastatin from the FDA, and is updated regularly. Simvastatin: Cautions. Simvastatin (5 to 80 mg/day) reduces the levels of total cholesterol (19 to 36%), LDL-cholesterol (26 to 47%), apolipoprotein B (19 to 38%), and triglycerides (12 to 33%), in patients with mild to severe hyperlipidemia (Fredrickson Types IIa and IIb). Sign Up to Receive Our Free Coroanvirus Newsletter, a condition with muscle tissue breakdown called rhabdomyolysis, a mother who is producing milk and breastfeeding, muscle pain or tenderness with increase creatine kinase, muscle problems related to the drug and having the SLCO1B1 gene. Atorvastatin — use with caution and adjust atorvastatin dose. simvastatin is now 20mg; higher doses are ‘off-label’. [See Contraindications (4) and Drug Interactions (7.1).] Liver function tests should be carried out. Patients should be closely monitored. Other interactions include [BNF 76, 2018]: In June 2011, the FDA placed new labeling restrictions on simvastatin. Simvastatin is contraindicated with pregnancy, breastfeeding, and liver disease. muscle pain or tenderness with increase creatine kinase. FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury See Drug Interaction table. There are 263 drug interactions with simvastatin. Liver function must be monitored regularly in the first year of treatment (e.g. Does Simvastatin Interact with other Medications? Liver function tests should be carried out. Patients cannot breastfeed while on simvastatin due to potentially disrupting the infant's lipid metabolism. Porphyria. memory loss. Pregnancy must be avoided while on simvastatin due to potentially severe birth defects. The combined use of simvastatin with gemfibrozil, cyclosporine, or danazol is contraindicated [see Contraindications (4) and Drug Interactions (7.1 and 7.2)]. Simvastatin disease interactions. Hypersensitivity to HMG-CoA reductase inhibitors. It is also used in the treatment of long-term complications such as heart disease or stroke. New MHRA recommendations on simvastatin interactions – implications for patients taking AMLODIPINE & SIMVASTATIN 40mg/day The August 2012 edition of the MHRA’s Drug Safety Update (vol 6, issue 1)1 highlights updated contraindications and dose recommendations for simvastatin when used with a number of other medicines. Other interactions include [BNF 76, 2018]: • 1. Temporary suspension of simvastatin treatment may be considered. All content is available under the Open Government Licence v3.0, except where otherwise stated, National restrictions in England until 2 December, Medicines and Healthcare products Regulatory Agency, Endocrinology, diabetology and metabolism, Simvastatin: increased risk of myopathy at high dose (80 mg), Simvastatin: dose limitations with concomitant amlodipine or diltiazem, Statins: interactions, and updated advice for atorvastatin, Ivabradine: carefully monitor for bradycardia, Systemic fusidic acid and interaction with statins, Coronavirus (COVID-19): guidance and support, Transparency and freedom of information releases. Ezetimibe; simvastatin is contraindicated in patients with active hepatic disease including cholestasis, hepatic encephalopathy, hepatitis, jaundice or unexplained persistent elevations in serum aminotransferase concentrations. Acute liver disease or unexplained persistent elevations of serum transaminases. Simvastatin drug interactions. Although rare, the most serious of these is rhabdomyolysis. Medscape - Hypercholesterolemia-specific dosing for Zocor (simvastatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & … New MHRA recommendations on simvastatin interactions – implications for patients taking AMLODIPINE & SIMVASTATIN 40mg/day The August 2012 edition of the MHRA’s Drug Safety Update (vol 6, issue 1)1 highlights updated contraindications and dose recommendations for simvastatin when used with a number of other medicines. Note that both itraconazole and statins can increase the risk of hepatotoxicity. Don’t include personal or financial information like your National Insurance number or credit card details. The TGA is advising health professionals to limit the prescribing of high dose (80 mg/day) simvastatin and to be aware of new contraindications and precautions for the use of simvastatin with other medicines. A full updated listing of all the interactions is provided in the table below. Common interactions include constipation among females and fatigue among males. Although all statins may be affected by drug interactions, simvastatin is exceptionally sensitive for several reasons. Amiodarone increases the risk of rhabdomyolysis when given with simvastatin. Common interactions include diarrhoea among females and dyspnoea among males. However, ... Concomitant use of drugs labeled as having a strong inhibitory effect on CYP3A4 is contraindicated [see Contraindications (4)]. The changes recommended against using 80-mg doses of simvastatin, added 4 drugs to the list of contraindicated agents, and included several new simvastatin dose limitations when prescribed with drugs that inhibit its elimination. A proper diet and regular exercise should be maintained along with taking this medicine. Niacin/Simvastatin drug interactions < Niacin. Start Drug Selection. Dosing : <10 years: Safety and efficacy not established. These changes have been driven by concerns over the risks of … Does Simvastatin Interact with other Medications? Caution should be used when prescribing other fibrates with simvastatin, as these agents can cause myopathy when given alone and the risk is increased when they are coadministered [see Drug Interactions (7.2) ] . Things to remember when you fill your prescription. Amiodarone. Although generally quite safe, the statins can be associated with a variety of serious side adverse effects, including myalgia, myopathy, and changes in plasma enzymes of hepatic origin. daily dose 10 mg and pack size of 28 tablets; treatment should form part of a programme to reduce risk of coronary heart disease. Severe Interactions. The combined use of ezetimibe and simvastatin tablets with gemfibrozil, cyclosporine, or danazol is contraindicated [see Contraindications and Drug Interactions (7.1 and 7.2)]. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Simvastatin: Contraindications. high blood sugar. every two months), later sporadic controls suffice. Simvastatin: new contraindications, precautions and dosage recommendations 6 December 2011 Patients on high dose simvastatin and those taking certain other medicines have an increased risk of developing myopathy (muscle weakness) and, more rarely, rhabdomyolysis 1 . Furthermore, this drug should not be taken if you are trying to become pregnant, are pregnant or if you are breastfeeding. Avoid grapefruit juice when taking simvastatin, simvastatin is now contraindicated with ciclosporin, danazol and gemfibrozil, the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day. 10–15 % risk of hepatotoxicity are not significantly metabolised by CYP3A4 and are therefore less likely to significant! 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